Molecule Details
InChIKeyWZZXMNBOPNKKSX-UHFFFAOYSA-N
Compound Name[3-[[4-[4-(3-Methoxy-4-phenoxyanilino)quinazolin-6-yl]phenyl]methyl]-3-azabicyclo[3.1.0]hexan-6-yl]methanol
Canonical SMILESCOc1cc(Nc2ncnc3ccc(-c4ccc(CN5CC6C(CO)C6C5)cc4)cc23)ccc1Oc1ccccc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)10
Pfam Stratification Cross-Family
Avg pChEMBL7.4
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (10)
Target Gene Organism Category Pfam pChEMBL Type Source
P04626 ERBB2 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 8.8 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 8.6 Ki ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 8.2 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 7.9 Ki ChEMBL
Q15303 ERBB4 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 7.8 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 7.2 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.5 Ki ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.4 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.3 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.3 Ki ChEMBL