Molecule Details
| InChIKey | WZOZEZRFJCJXNZ-ZBFHGGJFSA-N |
|---|---|
| Compound Name | Cefoxitin |
| Canonical SMILES | CO[C@@]1(NC(=O)Cc2cccs2)C(=O)N2C(C(=O)O)=C(COC(N)=O)CS[C@@H]21 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.65 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01331 |
|---|---|
| Drug Name | Cefoxitin |
| CAS Number | 35607-66-0 |
| Groups | approved investigational |
| ATC Codes | J01DC01 |
| Description | Cefoxitin is a semi-synthetic, broad-spectrum cepha antibiotic for intravenous administration. It is derived from cephamycin C, which is produced by <i>Streptomyces lactamdurans</i>. |
Categories: Amides Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use Cephalosporins Cephamycins Heterocyclic Compounds, Fused-Ring Lactams Nephrotoxic agents Second-Generation Cephalosporins Sulfur Compounds Thiazines beta-Lactams
Cross-references: BindingDB: 50335563 ChEBI: 209807 CHEMBL996 ChemSpider: 389981 Drugs Product Database (DPD): 11254 C06887 D02345 PDB: CFX PharmGKB: PA448856 PubChem:441199 PubChem:46505845 RxCUI: 2189 Therapeutic Targets Database: DAP000452 Wikipedia: Cefoxitin ZINC: ZINC000003830449
Target Activities (2)
DrugBank Target Actions (13)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P00808 | penP | Beta-lactamase | substrate | enzymes |
| P02918 | P02918 | Penicillin-binding protein 1A | inhibitor | targets |
| P02919 | P02919 | Penicillin-binding protein 1B | inhibitor | targets |
| P08506 | P08506 | D-alanyl-D-alanine carboxypeptidase DacC | inhibitor | targets |
| P0A3M6 | P0A3M6 | Penicillin-binding protein 2B | inhibitor | targets |
| P0AD68 | P0AD68 | Peptidoglycan D,D-transpeptidase FtsI | inhibitor | targets |
| P0AEB2 | P0AEB2 | D-alanyl-D-alanine carboxypeptidase DacA | inhibitor | targets |
| P0AFI5 | P0AFI5 | D-alanyl-D-alanine endopeptidase | inhibitor | targets |
| P24228 | P24228 | D-alanyl-D-alanine carboxypeptidase DacB | inhibitor | targets |
| Q75Y35 | Q75Y35 | serine-type D-Ala-D-Ala carboxypeptidase | inhibitor | targets |
| Q7CRA4 | Q7CRA4 | Penicillin-binding protein 1b | inhibitor | targets |
| Q8DNB6 | Q8DNB6 | Penicillin-binding protein 2a | inhibitor | targets |
| Q8DR59 | Q8DR59 | Penicillin-binding protein 1A | inhibitor | targets |