Molecule Details
InChIKeyWYBDIAZRTPZHAJ-UHFFFAOYSA-N
Compound Name1-[2-[[5-(4-Methylpiperazin-1-yl)-2-pyridinyl]amino]pyrimidin-4-yl]-1,4-diazaspiro[5.5]undecan-3-one
Canonical SMILESCN1CCN(c2ccc(Nc3nccc(N4CC(=O)NCC45CCCCC5)n3)nc2)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)6
Pfam Stratification Cross-Family
Avg pChEMBL6.16
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (6)
Target Gene Organism Category Pfam pChEMBL Type Source
P11802 CDK4 Homo sapiens Human PF00069 6.4 IC50 ChEMBL;BindingDB
P24385 CCND1 Homo sapiens Human PF02984 PF00134 6.4 IC50 ChEMBL
O60563 CCNT1 Homo sapiens Human PF00134 PF21797 6.1 IC50 ChEMBL;BindingDB
P50750 CDK9 Homo sapiens Human PF00069 6.1 IC50 ChEMBL
P30281 CCND3 Homo sapiens Human PF02984 PF00134 6.0 IC50 ChEMBL
Q00534 CDK6 Homo sapiens Human PF00069 6.0 IC50 ChEMBL;BindingDB