Molecule Details
InChIKeyWSPHMGORSRQULF-UHFFFAOYSA-N
Compound NamePF-06456384 trihydrochloride, >=98% (HPLC)
Canonical SMILESN#Cc1cc(S(=O)(=O)Nc2ncns2)ccc1Oc1ccc(-c2cccc(C(F)(F)F)c2)cc1-c1ccnc(CNCCC2CCNCC2)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)6
Pfam Stratification Cross-Family
Avg pChEMBL8.69
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (6)
Target Gene Organism Category Pfam pChEMBL Type Source
Q01118 SCN7A Homo sapiens Human PF00520 PF24609 PF06512 11.0 IC50 ChEMBL;BindingDB
Q15858 SCN9A Homo sapiens Human PF00520 PF24609 PF06512 PF11933 10.8 IC50 ChEMBL;BindingDB
Q99250 SCN2A Homo sapiens Human PF00520 PF24609 PF06512 PF11933 8.6 IC50 ChEMBL;BindingDB
Q9UQD0 SCN8A Homo sapiens Human PF00520 PF24609 PF06512 PF11933 8.2 IC50 ChEMBL;BindingDB
Q9GZV3 SLC5A7 Homo sapiens Human PF00474 7.0 IC50 ChEMBL;BindingDB
P35498 SCN1A Homo sapiens Human PF00520 PF24609 PF06512 PF11933 6.5 IC50 ChEMBL;BindingDB