InChIKey	WRFHGDPIDHPWIQ-UHFFFAOYSA-N
Canonical SMILES	CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2noc(C)c2C)c(COCC)c1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Homologous
Avg pChEMBL	8.56
Source	ChEMBL;BindingDB

DrugBank ID	DB12548
Drug Name	Sparsentan
CAS Number	254740-64-2
Groups	approved investigational
ATC Codes	C09XX01
Description	Sparsentan is a dual antagonist of the endothelin type A receptor (ET<sub>A</sub>R) and the angiotensin II (Ang II) type 1 receptor (AT<sub>1</sub>R) with a similar affinity for both (9.3 nM for ET<sub>A</sub>R and 0.8 nM for AT<sub>1</sub>R).[A257330,L45300] Sparsentan is first in its class and ora...

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Categories: Agents Acting on the Renin-Angiotensin System Amides Angiotensin 2 Receptor Blocker Angiotensin II Type 1 Receptor Blockers Angiotensin II receptor antagonists Angiotensin Receptor Antagonists BCRP/ABCG2 Inhibitors BCRP/ABCG2 Substrates Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inducers Cytochrome P-450 CYP2C19 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dual Endothelin Type A Receptor/Ang II Subtype 1 Receptor Antagonist (DEARA) Endothelin Receptor Antagonists OAT3/SLC22A8 Inhibitors OATP1B3 inhibitors P-glycoprotein inhibitors P-glycoprotein substrates Sulfones Sulfur Compounds

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Cross-references: BindingDB: 50175523 CHEMBL539423 ChemSpider: 8433365 PubChem:10257882 PubChem:347828773 RxCUI: 2630535 Wikipedia: Sparsentan