Molecule Details
InChIKeyWQAVGRAETZEADU-UHFFFAOYSA-N
Canonical SMILESCCc1cc2ncc(CN3CCN(c4ccc(C(=O)NC)nc4)CC3)cc2[nH]c1=O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL8.02
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB18982
Drug NameSaruparib
CAS Number2589531-76-8
Groups investigational
ATC Codes nan
DescriptionSaruparib is under investigation in clinical trial NCT06380751 (Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in Hr-positive, Her2-negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or Palb2m Advanced Breast Cancer).
Categories: Heterocyclic Compounds, Fused-Ring
Cross-references: CHEMBL5095220 ChemSpider: 114641973 PDB: A1H63
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P09874 PARP1 Homo sapiens Human PF00533 PF21728 PF00644 PF02877 PF05406 PF00645 PF08063 8.5 IC50 ChEMBL;BindingDB
Q9UGN5 PARP2 Homo sapiens Human PF00644 PF02877 PF05406 7.5 IC50 ChEMBL
DrugBank Target Actions (1)
Target Gene Target Name Action Type
P09874 PARP1 Poly [ADP-ribose] polymerase 1 inhibitor targets