Molecule Details
InChIKeyWPXVVAWAHQHJPF-UHFFFAOYSA-N
Compound Name1-(5-Tert-butyl-1,2-oxazol-3-yl)-3-[4-(6,7,8,9-tetrahydropyrimido[5,4-b][1,4]oxazepin-4-ylamino)phenyl]urea
Canonical SMILESCC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)41
Pfam Stratification Cross-Family
Avg pChEMBL6.81
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (41)
Target Gene Organism Category Pfam pChEMBL Type Source
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 8.2 IC50 ChEMBL;BindingDB
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 8.1 IC50 ChEMBL;BindingDB
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 8.1 IC50 ChEMBL;BindingDB
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 8.0 IC50 ChEMBL;BindingDB
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.9 IC50 ChEMBL;BindingDB
Q9NYL2 MAP3K20 Homo sapiens Human PF07714 PF07647 7.7 IC50 ChEMBL;BindingDB
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 7.7 IC50 ChEMBL;BindingDB
Q15759 MAPK11 Homo sapiens Human PF00069 7.3 IC50 ChEMBL;BindingDB
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 7.3 IC50 ChEMBL;BindingDB
Q16832 DDR2 Homo sapiens Human PF21114 PF00754 PF07714 7.3 IC50 ChEMBL;BindingDB
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 7.2 IC50 ChEMBL;BindingDB
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 7.2 IC50 ChEMBL;BindingDB
P08631 HCK Homo sapiens Human PF07714 PF00017 PF00018 7.1 IC50 ChEMBL;BindingDB
P29317 EPHA2 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 7.0 IC50 ChEMBL;BindingDB
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.9 IC50 ChEMBL;BindingDB
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.9 IC50 ChEMBL;BindingDB
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.9 IC50 ChEMBL;BindingDB
P51617 IRAK1 Homo sapiens Human PF00531 PF00069 6.8 IC50 ChEMBL;BindingDB
P53778 MAPK12 Homo sapiens Human PF00069 6.7 IC50 ChEMBL;BindingDB
Q15375 EPHA7 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 6.7 IC50 ChEMBL;BindingDB
O15264 MAPK13 Homo sapiens Human PF00069 6.7 IC50 ChEMBL;BindingDB
P10721 KIT Homo sapiens Human PF00047 PF07714 6.7 IC50 ChEMBL;BindingDB
Q9UKE5 TNIK Homo sapiens Human PF00780 PF00069 6.7 IC50 ChEMBL;BindingDB
P04049 RAF1 Homo sapiens Human PF00130 PF07714 PF02196 6.6 IC50 ChEMBL;BindingDB
P16234 PDGFRA Homo sapiens Human PF07679 PF25305 PF07714 6.6 IC50 ChEMBL;BindingDB
Q08881 ITK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.5 IC50 ChEMBL;BindingDB
P54762 EPHB1 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 6.4 IC50 ChEMBL;BindingDB
Q02763 TEK Homo sapiens Human PF00041 PF10430 PF07714 6.4 IC50 ChEMBL;BindingDB
O43318 MAP3K7 Homo sapiens Human PF07714 6.3 IC50 ChEMBL;BindingDB
Q9BYP7 WNK3 Homo sapiens Human PF24889 PF12202 PF00069 6.3 IC50 ChEMBL;BindingDB
P48730 CSNK1D Homo sapiens Human PF00069 6.3 IC50 ChEMBL;BindingDB
P29320 EPHA3 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF07647 6.3 IC50 ChEMBL;BindingDB
P09619 PDGFRB Homo sapiens Human PF00047 PF13927 PF25305 PF07714 6.2 IC50 ChEMBL;BindingDB
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 6.2 IC50 ChEMBL;BindingDB
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.2 IC50 ChEMBL;BindingDB
O60563 CCNT1 Homo sapiens Human PF00134 PF21797 6.1 IC50 ChEMBL;BindingDB
P50750 CDK9 Homo sapiens Human PF00069 6.1 IC50 ChEMBL
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 6.1 IC50 ChEMBL;BindingDB
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.0 IC50 ChEMBL;BindingDB
Q9UL54 TAOK2 Homo sapiens Human PF00069 6.0 IC50 ChEMBL;BindingDB
P15056 BRAF Homo sapiens Human PF00130 PF07714 PF02196 6.0 IC50 ChEMBL;BindingDB