Molecule Details
InChIKeyWPNJAUFVNXKLIM-UHFFFAOYSA-N
Compound NameMoxonidine
Canonical SMILESCOc1nc(C)nc(Cl)c1NC1=NCCN1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)4
Pfam Stratification Cross-Family
Avg pChEMBL7.4
SourceChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB09242
Drug NameMoxonidine
CAS Number75438-57-2
Groups approved investigational withdrawn
ATC Codes C02AC05 C02LC05
DescriptionMoxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate ...

Categories: Adrenergic Agonists Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists Agents producing tachycardia Agents that produce hypertension Antiadrenergic Agents, Centrally Acting Antihypertensive Agents Cardiovascular Agents Hypotensive Agents Imidazoline Receptor Agonists Sympatholytics
Cross-references: BindingDB: 50050093 ChEBI: 7009 CHEMBL19236 ChemSpider: 4645 C07451 D05087 PubChem:4810 PubChem:310265145 RxCUI: 30257 Wikipedia: Moxonidine ZINC: ZINC000001854466
Target Activities (4)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9Y2I1 NISCH Homo sapiens Human PF25625 PF23142 PF00787 8.4 Ki ChEMBL
P18089 ADRA2B Homo sapiens Human PF00001 7.1 Ki ChEMBL
P18825 ADRA2C Homo sapiens Human PF00001 7.1 Ki ChEMBL
P08913 ADRA2A Homo sapiens Human PF00001 7.0 Ki ChEMBL
DrugBank Target Actions (4)
Target Gene Target Name Action Type
P08913 ADRA2A Alpha-2A adrenergic receptor agonist targets
Q9Y2I1 NISCH Nischarin agonist targets
P18089 ADRA2B Alpha-2B adrenergic receptor inhibitor targets
P18825 ADRA2C Alpha-2C adrenergic receptor inhibitor targets