N-[4-[4-(4-aminopiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide

InChIKey	`WNQHVGYFQUHRNW-UHFFFAOYSA-N`
Compound Name	N-[4-[4-(4-aminopiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide
Canonical SMILES	`Cc1cc(Nc2cc(N3CCN(N)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	4
Pfam Stratification	Homologous
Avg pChEMBL	8.53
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
O14965	AURKA	Homo sapiens	Human	PF00069	9.2	Ki	ChEMBL
Q96GD4	AURKB	Homo sapiens	Human	PF00069	8.5	Ki	ChEMBL
Q9UQB9	AURKC	Homo sapiens	Human	PF00069	8.3	Ki	ChEMBL
O00444	PLK4	Homo sapiens	Human	PF00069 PF18190 PF18409	8.1	Ki	ChEMBL