InChIKey	WMWTYOKRWGGJOA-CENSZEJFSA-N
Compound Name	Fluticasone Propionate
Canonical SMILES	CCC(=O)O[C@]1(C(=O)SCF)[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	4
Pfam Stratification	Cross-Family
Avg pChEMBL	8.61
Source	BindingDB;ChEMBL

DrugBank ID	DB00588
Drug Name	Fluticasone propionate
CAS Number	80474-14-2
Groups	approved investigational
ATC Codes	nan
Description	Fluticasone propionate is a synthetic glucocorticoid[F4355,F4358][FDA Label]. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358][FDA Label]. Fluticasone propionate was first approved in 1990[L5962].

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Categories: Adrenal Cortex Hormones Adrenals Agents to Treat Airway Disease Androstadienes Androstanes Androstenes Anti-Allergic Agents Anti-Asthmatic Agents Anti-Inflammatory Agents Autonomic Agents Bronchodilator Agents Central Nervous System Depressants Corticosteroids Corticosteroids, Dermatological Preparations Corticosteroids, Potent (Group III) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Inhibitors (strength unknown) Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Fused-Ring Compounds Glucocorticoids Immunosuppressive Agents OATP1B1/SLCO1B1 Inhibitors P-glycoprotein substrates Peripheral Nervous System Agents Respiratory System Agents Steroids Thyroxine-binding globulin inhibitors

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Cross-references: BindingDB: 50354849 ChEBI: 31441 CHEMBL1473 ChemSpider: 392059 Drugs Product Database (DPD): 637 D01708 PharmGKB: PA449686 PubChem:444036 PubChem:46506140 RxCUI: 50121 Therapeutic Targets Database: DAP001039 Wikipedia: Fluticasone_propionate ZINC: ZINC000003920027