Molecule Details
InChIKeyWMTXIPYJYDISKM-UHFFFAOYSA-N
Compound Name6-(4-piperazin-1-ylphenyl)-3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine
Canonical SMILESc1cc(N2CCNCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)8
Pfam Stratification Cross-Family
Avg pChEMBL7.3
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (8)
Target Gene Organism Category Pfam pChEMBL Type Source
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.8 IC50 ChEMBL
P37173 TGFBR2 Homo sapiens Human PF08917 PF07714 7.4 IC50 ChEMBL;BindingDB
Q04771 ACVR1 Homo sapiens Human PF01064 PF07714 PF08515 7.4 IC50 ChEMBL;BindingDB
P36894 BMPR1A Homo sapiens Human PF01064 PF07714 PF08515 7.3 IC50 ChEMBL;BindingDB
P37023 ACVRL1 Homo sapiens Human PF07714 PF08515 7.3 IC50 ChEMBL;BindingDB
Q13873 BMPR2 Homo sapiens Human PF01064 PF00069 7.2 IC50 ChEMBL;BindingDB
Q9Y478 PRKAB1 Homo sapiens Human PF16561 PF04739 7.1 IC50 ChEMBL;BindingDB
O00238 BMPR1B Homo sapiens Human PF01064 PF07714 PF08515 6.9 IC50 ChEMBL;BindingDB