Molecule Details
| InChIKey | WKINNFHNVQMBKZ-UHFFFAOYSA-N |
|---|---|
| Compound Name | 3-Tert-butyl-5-(4-fluorophenyl)-1-(2-hydroxyethyl)-6,7-dihydropyrazolo[4,5-e][1,4]diazepin-8-one |
| Canonical SMILES | CC(C)(C)c1nn(CCO)c2c1N=C(c1ccc(F)cc1)CNC2=O |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.33 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P27815 | PDE4A | Homo sapiens | Human | PF18100 PF00233 | 7.5 | IC50 | ChEMBL |
| Q07343 | PDE4B | Homo sapiens | Human | PF18100 PF00233 | 7.5 | IC50 | ChEMBL;BindingDB |
| Q08493 | PDE4C | Homo sapiens | Human | PF18100 PF00233 | 7.5 | IC50 | ChEMBL |
| Q08499 | PDE4D | Homo sapiens | Human | PF18100 PF00233 | 7.5 | IC50 | ChEMBL |
| O00408 | PDE2A | Homo sapiens | Human | PF01590 PF00233 | 6.6 | IC50 | ChEMBL;BindingDB |