Molecule Details
InChIKeyWKDNQONLGXOZRG-HRNNMHKYSA-N
Canonical SMILESCC#Cc1cncc(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL8.24
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB14814
Drug NameLanabecestat
CAS Number1383982-64-6
Groups investigational
ATC Codes nan
DescriptionLanabecestat is under investigation in clinical trial NCT03499041 (A Study of LY3314814 in Participants With Liver Impairment).

Cross-references: BindingDB: 136735 CHEMBL3989948 ChemSpider: 58177815 Wikipedia: Lanabecestat
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P05067 APP Homo sapiens Human PF10515 PF12924 PF12925 PF02177 PF03494 PF00014 9.4 IC50 ChEMBL;BindingDB
P56817 BACE1 Homo sapiens Human PF00026 8.9 IC50 ChEMBL;BindingDB
Q9Y5Z0 BACE2 Homo sapiens Human PF00026 6.4 Ki ChEMBL;BindingDB