Molecule Details
InChIKeyWJRRGYBTGDJBFX-UHFFFAOYSA-N
Compound Name4-(2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)-2-pyrimidinamine
Canonical SMILESCc1ncc(-c2ccnc(Nc3ccc(S(C)(=O)=O)cc3)n2)n1C(C)C
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)16
Pfam Stratification Cross-Family
Avg pChEMBL7.33
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (16)
Target Gene Organism Category Pfam pChEMBL Type Source
P24864 CCNE1 Homo sapiens Human PF02984 PF00134 8.2 IC50 ChEMBL;BindingDB
P24941 CDK2 Homo sapiens Human PF00069 8.2 pIC50 TTD_MultiTarget
P06493 CDK1 Homo sapiens Human PF00069 7.8 IC50 ChEMBL;BindingDB
P14635 CCNB1 Homo sapiens Human PF02984 PF00134 7.8 IC50 ChEMBL;BindingDB
P11802 CDK4 Homo sapiens Human PF00069 7.7 pIC50 TTD_MultiTarget
O60563 CCNT1 Homo sapiens Human PF00134 PF21797 7.7 IC50 ChEMBL;BindingDB
P50750 CDK9 Homo sapiens Human PF00069 7.7 IC50 ChEMBL
P30281 CCND3 Homo sapiens Human PF02984 PF00134 7.7 IC50 ChEMBL;BindingDB
Q00534 CDK6 Homo sapiens Human PF00069 7.7 IC50 ChEMBL
P20248 CCNA2 Homo sapiens Human PF02984 PF00134 PF16500 7.3 IC50 ChEMBL;BindingDB
P49840 GSK3A Homo sapiens Human PF00069 7.3 Kd ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 7.2 Kd ChEMBL
Q2M2I8 AAK1 Homo sapiens Human PF00069 6.6 Kd ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.2 Kd ChEMBL
Q9Y616 IRAK3 Homo sapiens Human PF00531 PF00069 6.1 Kd ChEMBL
Q9NSY1 BMP2K Homo sapiens Human PF15282 PF00069 6.1 Kd ChEMBL