Molecule Details
| InChIKey | WJCNZQLZVWNLKY-UHFFFAOYSA-N |
|---|---|
| Compound Name | Thiabendazole |
| Canonical SMILES | c1ccc2[nH]c(-c3cscn3)nc2c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.29 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00730 |
|---|---|
| Drug Name | Thiabendazole |
| CAS Number | 148-79-8 |
| Groups | approved vet_approved withdrawn |
| ATC Codes | D01AC06 P02CA02 |
| Description | 2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for strongyloidiasis. It has CNS side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919) |
Categories: Anthelmintics Anti-Infective Agents Antifungals for Dermatological Use Antifungals for Topical Use Antihelminthic Antinematodal Agents Antiparasitic Agents Antiparasitic Products, Insecticides and Repellents Benzimidazole Derivatives Benzimidazoles Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Drugs that are Mainly Renally Excreted Heterocyclic Compounds, Fused-Ring Imidazole and Triazole Derivatives Sulfur Compounds Thiazoles
Cross-references: BindingDB: 50121347 ChEBI: 45979 CHEMBL625 ChemSpider: 5237 Drugs Product Database (DPD): 9707 C07131 D00372 PDB: TMG PharmGKB: PA164746466 PubChem:5430 PubChem:46505131 RxCUI: 10450 Therapeutic Targets Database: DAP000664 Wikipedia: Tiabendazole ZINC: ZINC000000073711