2-[(2-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluorobenzamide

InChIKey	`WHVFDYQCAMPLMS-UHFFFAOYSA-N`
Compound Name	2-[(2-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluorobenzamide
Canonical SMILES	`COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	20
Pfam Stratification	Cross-Family
Avg pChEMBL	7.38
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P06729	CD2	Homo sapiens	Human	PF05790 PF07686	9.0	pIC50	TTD_MultiTarget
Q9UM73	ALK	Homo sapiens	Human	PF12810 PF00629 PF07714	8.9	Ki	ChEMBL
P16591	FER	Homo sapiens	Human	PF00611 PF07714 PF00017	8.8	Ki	ChEMBL
P29376	LTK	Homo sapiens	Human	PF12810 PF07714	8.8	Ki	ChEMBL
P08069	IGF1R	Homo sapiens	Human	PF00757 PF07714 PF01030	8.7	IC50	ChEMBL;BindingDB
P08922	ROS1	Homo sapiens	Human	PF00041 PF07714	8.6	Ki	ChEMBL
Q5S007	LRRK2	Homo sapiens	Human	PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477	8.1	Ki	ChEMBL
Q9HAZ1	CLK4	Homo sapiens	Human	PF00069	7.7	Ki	ChEMBL
P49760	CLK2	Homo sapiens	Human	PF00069	7.5	Ki	ChEMBL
Q05397	PTK2	Homo sapiens	Human	PF21477 PF00373 PF18038 PF03623 PF07714	7.4	Ki	ChEMBL
O43293	DAPK3	Homo sapiens	Human	PF00069	7.0	Ki	ChEMBL
P30530	AXL	Homo sapiens	Human	PF00041 PF13927 PF07714	6.9	Ki	ChEMBL
P45983	MAPK8	Homo sapiens	Human	PF00069	6.8	Ki	ChEMBL
O94806	PRKD3	Homo sapiens	Human	PF00130 PF00169 PF00069 PF25525	6.4	Ki	ChEMBL
P34947	GRK5	Homo sapiens	Human	PF00069 PF00615	6.3	Ki	ChEMBL
O00311	CDC7	Homo sapiens	Human	PF00069	6.2	Ki	ChEMBL
P45984	MAPK9	Homo sapiens	Human	PF00069	6.2	Ki	ChEMBL
P51812	RPS6KA3	Homo sapiens	Human	PF00069 PF00433	6.2	Ki	ChEMBL
P68400	CSNK2A1	Homo sapiens	Human	PF00069	6.2	Ki	ChEMBL
P05129	PRKCG	Homo sapiens	Human	PF00130 PF00168 PF00069 PF00433	6.0	Ki	ChEMBL