Molecule Details
| InChIKey | WHUUTDBJXJRKMK-VKHMYHEASA-N |
|---|---|
| Compound Name | L-Glutamic Acid |
| Canonical SMILES | N[C@@H](CCC(=O)O)C(=O)O |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 20 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.75 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00142 |
|---|---|
| Drug Name | Glutamic acid |
| CAS Number | 56-86-0 |
| Groups | approved investigational nutraceutical |
| ATC Codes | A09AB01 |
| Description | A peptide that is a homopolymer of glutamic acid. |
Categories: Acid Preparations Alimentary Tract and Metabolism Amino Acids Amino Acids, Acidic Amino Acids, Dicarboxylic Amino Acids, Peptides, and Proteins Dietary Supplements Digestives, Incl. Enzymes Excitatory Amino Acids Gastrointestinal Acidifying Agents Gastrointestinal Agents Glutamates Proteinogenic Amino Acids Supplements
Cross-references: BindingDB: 17657 ChEBI: 16015 CHEMBL575060 ChemSpider: 30572 Drugs Product Database (DPD): 8872 Guide to Pharmacology: 1369 IUPHAR: 1369 C00025 D00007 PDB: GGL PharmGKB: PA449776 PubChem:33032 PubChem:46505816 RxCUI: 25916 Therapeutic Targets Database: DAP000015 Wikipedia: Glutamic_acid ZINC: ZINC000001482113
Target Activities (20)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O00222 | GRM8 | Homo sapiens | Human | PF00003 PF01094 PF07562 | 8.2 | IC50 | ChEMBL;BindingDB |
| P43005 | SLC1A1 | Homo sapiens | Human | PF00375 | 7.3 | Ki | ChEMBL;BindingDB |
| Q14832 | GRM3 | Homo sapiens | Human | PF00003 PF01094 PF07562 | 7.2 | Ki | ChEMBL |
| O15399 | GRIN2D | Homo sapiens | Human | PF01094 PF00060 PF10613 | 7.2 | IC50 | ChEMBL |
| O60391 | GRIN3B | Homo sapiens | Human | PF00060 PF10613 | 7.2 | IC50 | ChEMBL |
| Q05586 | GRIN1 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 7.2 | IC50 | ChEMBL |
| Q12879 | GRIN2A | Homo sapiens | Human | PF01094 PF00060 PF10613 PF10565 | 7.2 | IC50 | ChEMBL |
| Q13224 | GRIN2B | Homo sapiens | Human | PF01094 PF00060 PF10613 PF10565 | 7.2 | IC50 | ChEMBL |
| Q14957 | GRIN2C | Homo sapiens | Human | PF01094 PF00060 PF10613 PF10565 | 7.2 | IC50 | ChEMBL |
| Q8TCU5 | GRIN3A | Homo sapiens | Human | PF01094 PF00060 PF10613 | 7.2 | IC50 | ChEMBL |
| P42263 | GRIA3 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.5 | Ki | ChEMBL;BindingDB |
| Q13255 | GRM1 | Homo sapiens | Human | PF00003 PF01094 PF10606 PF07562 | 6.4 | Ki | ChEMBL;BindingDB |
| P41594 | GRM5 | Homo sapiens | Human | PF00003 PF01094 PF10606 PF07562 | 6.4 | Ki | ChEMBL;BindingDB |
| P42261 | GRIA1 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.3 | IC50 | ChEMBL |
| P39086 | GRIK1 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.2 | Ki | ChEMBL;BindingDB |
| Q16478 | GRIK5 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.1 | Ki | ChEMBL;BindingDB |
| Q13003 | GRIK3 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.1 | Ki | ChEMBL;BindingDB |
| P48058 | GRIA4 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.1 | Ki | ChEMBL;BindingDB |
| P42262 | GRIA2 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.0 | Ki | ChEMBL;BindingDB |
| A0A0V1DID4 | CNRIP1 | Trichinella britovi | Pathogen | PF15043 | 6.0 | Ki | BindingDB |
DrugBank Target Actions (68)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| O00222 | GRM8 | Metabotropic glutamate receptor 8 | binder | targets |
| O00341 | O00341 | Excitatory amino acid transporter 5 | binder | targets |
| O14841 | O14841 | 5-oxoprolinase | binder | targets |
| O15067 | O15067 | Phosphoribosylformylglycinamidine synthase | binder | targets |
| O15382 | BCAT2 | Branched-chain-amino-acid aminotransferase, mitochondrial | binder | targets |
| O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | binder | targets |
| O94925 | GLS | Glutaminase kidney isoform, mitochondrial | binder | targets |
| O95954 | O95954 | Formimidoyltransferase-cyclodeaminase | binder | targets |
| P00367 | P00367 | Glutamate dehydrogenase 1, mitochondrial | binder | targets |
| P00505 | P00505 | Aspartate aminotransferase, mitochondrial | binder | targets |
| P07814 | EPRS1 | Bifunctional glutamate/proline--tRNA ligase | binder | targets |
| P08243 | ASNS | Asparagine synthetase [glutamine-hydrolyzing] | binder | targets |
| P15104 | P15104 | Glutamine synthetase | binder | targets |
| P17174 | GOT1 | Aspartate aminotransferase, cytoplasmic | binder | targets |
| P17735 | P17735 | Tyrosine aminotransferase | binder | targets |
| P24298 | P24298 | Alanine aminotransferase 1 | binder | targets |
| P38435 | P38435 | Vitamin K-dependent gamma-carboxylase | binder | targets |
| P39086 | GRIK1 | Glutamate receptor ionotropic, kainate 1 | binder | targets |
| P42261 | GRIA1 | Glutamate receptor 1 | binder | targets |
| P42262 | GRIA2 | Glutamate receptor 2 | binder | targets |
| P42263 | GRIA3 | Glutamate receptor 3 | binder | targets |
| P43003 | SLC1A3 | Excitatory amino acid transporter 1 | binder | targets |
| P43004 | SLC1A2 | Excitatory amino acid transporter 2 | binder | targets |
| P43005 | SLC1A1 | Excitatory amino acid transporter 3 | binder | targets |
| P48058 | GRIA4 | Glutamate receptor 4 | binder | targets |
| P48507 | P48507 | Glutamate--cysteine ligase regulatory subunit | binder | targets |
| P48664 | P48664 | Excitatory amino acid transporter 4 | binder | targets |
| P49915 | GMPS | GMP synthase [glutamine-hydrolyzing] | binder | targets |
| P54687 | BCAT1 | Branched-chain-amino-acid aminotransferase, cytosolic | binder | targets |
| P54886 | P54886 | Delta-1-pyrroline-5-carboxylate synthase | binder | targets |
| P80404 | ABAT | 4-aminobutyrate aminotransferase, mitochondrial | binder | targets |
| Q04609 | FOLH1 | Glutamate carboxypeptidase 2 | binder | targets |
| Q05329 | Q05329 | Glutamate decarboxylase 2 | binder | targets |
| Q05586 | GRIN1 | Glutamate receptor ionotropic, NMDA 1 | binder | targets |
| Q05932 | FPGS | Folylpolyglutamate synthase, mitochondrial | binder | targets |
| Q07075 | ENPEP | Glutamyl aminopeptidase | binder | targets |
| Q12879 | GRIN2A | Glutamate receptor ionotropic, NMDA 2A | binder | targets |
| Q13002 | GRIK2 | Glutamate receptor ionotropic, kainate 2 | binder | targets |
| Q13003 | GRIK3 | Glutamate receptor ionotropic, kainate 3 | binder | targets |
| Q13224 | GRIN2B | Glutamate receptor ionotropic, NMDA 2B | binder | targets |
| Q13255 | GRM1 | Metabotropic glutamate receptor 1 | binder | targets |
| Q14831 | GRM7 | Metabotropic glutamate receptor 7 | binder | targets |
| Q14833 | GRM4 | Metabotropic glutamate receptor 4 | binder | targets |
| Q14957 | GRIN2C | Glutamate receptor ionotropic, NMDA 2C | binder | targets |
| Q16099 | GRIK4 | Glutamate receptor ionotropic, kainate 4 | binder | targets |
| Q16478 | GRIK5 | Glutamate receptor ionotropic, kainate 5 | binder | targets |
| Q5JPH6 | Q5JPH6 | Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial | binder | targets |
| Q8N159 | Q8N159 | N-acetylglutamate synthase, mitochondrial | binder | targets |
| Q8N5Z0 | AADAT | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | binder | targets |
| Q8TCU5 | GRIN3A | Glutamate receptor ionotropic, NMDA 3A | binder | targets |
| Q99259 | Q99259 | Glutamate decarboxylase 1 | binder | targets |
| Q9UDR5 | Q9UDR5 | Alpha-aminoadipic semialdehyde synthase, mitochondrial | binder | targets |
| Q9UI32 | GLS2 | Glutaminase liver isoform, mitochondrial | binder | targets |
| Q9ULA0 | DNPEP | Aspartyl aminopeptidase | binder | targets |
| Q9UPY5 | SLC7A11 | Cystine/glutamate transporter | binder | targets |
| Q9Y617 | PSAT1 | Phosphoserine aminotransferase | binder | targets |
| Q9Y646 | Q9Y646 | Carboxypeptidase Q | binder | targets |
| Q6IA69 | Q6IA69 | Glutamine-dependent NAD(+) synthetase | product of | targets |
| Q8TD30 | Q8TD30 | Alanine aminotransferase 2 | product of | targets |
| P17174 | GOT1 | Aspartate aminotransferase | substrate | targets |
| P48506 | P48506 | Glutamate--cysteine ligase catalytic subunit | substrate | targets |
| P49448 | GLUD2 | Glutamate dehydrogenase 2, mitochondrial | substrate | targets |
| Q8TD30 | Q8TD30 | Alanine aminotransferase 2 | substrate | targets |
| Q9H1K4 | Q9H1K4 | Mitochondrial glutamate carrier 2 | binder | transporters |
| Q9H936 | Q9H936 | Mitochondrial glutamate carrier 1 | binder | transporters |
| Q8TF71 | Q8TF71 | Monocarboxylate transporter 10 | inhibitor | transporters |
| P53985 | SLC16A1 | Monocarboxylate transporter 1 | substrate | transporters |
| Q8TF71 | Q8TF71 | Monocarboxylate transporter 10 | substrate | transporters |