Molecule Details
InChIKeyWHMMKPWGWNYYFE-UHFFFAOYSA-N
Canonical SMILESCOc1cc2nccc(Oc3ccc(NC(=O)c4cc5c(n(-c6ccccc6)c4=O)CCCC5=O)nc3)c2cc1OC
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL8.46
SourceChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB19201
Drug NameTamnorzatinib
CAS Number1646839-59-9
Groups investigational
ATC Codes nan
DescriptionTamnorzatinib is under investigation in clinical trial NCT03176277 (A Study of ONO-7475 in Patients With Acute Leukemias).
Cross-references: ChemSpider: 84393657
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 8.9 IC50 ChEMBL
Q12866 MERTK Homo sapiens Human PF00041 PF00047 PF13927 PF07714 8.0 IC50 ChEMBL
DrugBank Target Actions (2)
Target Gene Target Name Action Type
P30530 AXL Tyrosine-protein kinase receptor UFO inhibitor targets
Q12866 MERTK Tyrosine-protein kinase Mer inhibitor targets