InChIKey	WHBIGIKBNXZKFE-UHFFFAOYSA-N
Compound Name	Delavirdine
Canonical SMILES	CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(NS(C)(=O)=O)ccc3[nH]2)CC1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	7.5
Source	BindingDB;ChEMBL

DrugBank ID	DB00705
Drug Name	Delavirdine
CAS Number	136817-59-9
Groups	approved withdrawn
ATC Codes	J05AG02
Description	A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.

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Categories: Anti-HIV Agents Anti-Infective Agents Anti-Retroviral Agents Antiinfectives for Systemic Use Antiviral Agents Antivirals for Systemic Use Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (strong) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strong) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Inhibitors (strength unknown) Cytochrome P-450 CYP3A7 Inhibitors Cytochrome P-450 CYP3A7 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Direct Acting Antivirals Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor Indoles Non-Nucleoside Reverse Transcriptase Inhibitors Nonnucleoside Reverse Transcriptase Inhibitors Nucleic Acid Synthesis Inhibitors Piperazines Reverse Transcriptase Inhibitors

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Cross-references: BindingDB: 1944 ChEBI: 119573 CHEMBL593 ChemSpider: 5423 Drugs Product Database (DPD): 11786 C06941 PDB: SPP PharmGKB: PA449223 PubChem:5625 PubChem:46508878 RxCUI: 83816 Therapeutic Targets Database: DAP000183 Wikipedia: Delavirdine ZINC: ZINC000018516586