Molecule Details
InChIKeyWGYPOAXANMFHMT-UHFFFAOYSA-N
Compound Name3-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4,5-dihydrothiazol-2-yl)benzamide
Canonical SMILESCC(C)n1nc(-c2cccc(C(=O)NC3=NCCS3)c2)c2c(N)ncnc21
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)10
Pfam Stratification Cross-Family
Avg pChEMBL6.87
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (10)
Target Gene Organism Category Pfam pChEMBL Type Source
Q8N122 RPTOR Homo sapiens Human PF02985 PF14538 PF00400 8.1 IC50 ChEMBL
Q9BVC4 MLST8 Homo sapiens Human PF00400 8.1 IC50 ChEMBL;BindingDB
P42345 MTOR Homo sapiens Human PF02259 PF02260 PF08771 PF23593 PF11865 PF00454 7.1 pIC50 TTD_MultiTarget
Q6R327 RICTOR Homo sapiens Human PF14663 PF14666 PF14664 PF14665 PF14668 7.1 IC50 ChEMBL
Q9BPZ7 MAPKAP1 Homo sapiens Human PF16978 PF25322 PF05422 PF16979 7.1 IC50 ChEMBL;BindingDB
P78527 PRKDC Homo sapiens Human PF20500 PF20502 PF08163 PF19704 PF02259 PF02260 PF00454 6.5 IC50 ChEMBL
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 6.4 pIC50 TTD_MultiTarget
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.2 IC50 ChEMBL
O00329 PIK3CD Homo sapiens Human PF00454 PF00792 PF02192 PF00794 PF00613 6.2 IC50 ChEMBL
P48736 PIK3CG Homo sapiens Human PF00454 PF00792 PF00794 PF00613 PF19710 6.0 IC50 ChEMBL