Molecule Details
InChIKeyWFRLFWGASBLYTC-UHFFFAOYSA-N
Compound NameN-(2-Chloro-6-methylphenyl)-2-((2,6-dimethyl-4-pyrimidinyl)amino)-5-thiazolecarboxamide
Canonical SMILESCc1cc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)nc(C)n1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)15
Pfam Stratification Cross-Family
Avg pChEMBL8.0
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (15)
Target Gene Organism Category Pfam pChEMBL Type Source
P09769 FGR Homo sapiens Human PF07714 PF00017 PF00018 9.1 IC50 ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 9.0 IC50 ChEMBL;BindingDB
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 9.0 IC50 ChEMBL;BindingDB
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 8.8 pIC50 TTD_MultiTarget
P07947 YES1 Homo sapiens Human PF07714 PF00017 PF00018 8.7 IC50 ChEMBL
P08631 HCK Homo sapiens Human PF07714 PF00017 PF00018 8.7 IC50 ChEMBL;BindingDB
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 8.5 IC50 ChEMBL
P11274 BCR Homo sapiens Human PF09036 PF00168 PF19057 PF00620 PF00621 8.5 IC50 ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 8.4 IC50 ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 8.2 IC50 ChEMBL;BindingDB
O15264 MAPK13 Homo sapiens Human PF00069 6.7 IC50 ChEMBL
P53778 MAPK12 Homo sapiens Human PF00069 6.7 IC50 ChEMBL
Q15759 MAPK11 Homo sapiens Human PF00069 6.7 IC50 ChEMBL
Q16539 MAPK14 Homo sapiens Human PF00069 6.7 IC50 ChEMBL
P04626 ERBB2 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.3 pIC50 TTD_MultiTarget