Molecule Details
| InChIKey | WAOQONBSWFLFPE-VIFPVBQESA-N |
|---|---|
| Compound Name | Raclopride |
| Canonical SMILES | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(Cl)c1OC |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.92 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB12518 |
|---|---|
| Drug Name | Raclopride |
| CAS Number | 84225-95-6 |
| Groups | investigational |
| ATC Codes | nan |
| Description | Raclopride has been used in trials studying Parkinson Disease. |
Categories: Acids, Carbocyclic Amides Antipsychotic Agents Benzamides and benzamide derivatives Benzene Derivatives Benzoates Central Nervous System Agents Central Nervous System Depressants Chlorobenzoates Dopamine Agents Dopamine Antagonists Dopamine D2 Receptor Antagonists Neurotoxic agents Neurotransmitter Agents Psychotropic Drugs Tranquilizing Agents
Cross-references: BindingDB: 50005118 ChEBI: 92070 CHEMBL8809 ChemSpider: 2298373 PubChem:3033769 PubChem:347828748 Wikipedia: Raclopride ZINC: ZINC000025757754
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P21728 | DRD1 | Homo sapiens | Human | PF00001 | 8.2 | Ki | ChEMBL |
| P21918 | DRD5 | Homo sapiens | Human | PF00001 | 8.2 | Ki | ChEMBL |
| P35462 | DRD3 | Homo sapiens | Human | PF00001 | 8.1 | Ki | ChEMBL;BindingDB |
| P14416 | DRD2 | Homo sapiens | Human | PF00001 | 8.0 | Ki | ChEMBL;BindingDB |
| P21917 | DRD4 | Homo sapiens | Human | PF00001 | 7.1 | Ki | ChEMBL;BindingDB |