Molecule Details
InChIKeyVWXRQYYUEIYXCZ-OBIMUBPZSA-N
Compound NameAtosiban
Canonical SMILESCCOc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)4
Pfam Stratification Homologous
Avg pChEMBL7.61
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB09059
Drug NameAtosiban
CAS Number90779-69-4
Groups approved investigational
ATC Codes G02CX01
DescriptionAtosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used intravenously to halt premature labor. Although initial studies suggested it could be used as a nasal spray and hence would not require hospital admission, it is not used in that form. Atobisan was developed by the Swedish...

Categories: Amino Acids, Peptides, and Proteins Genito Urinary System and Sex Hormones Hormone Antagonists Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Peptide Hormones Peptides Pituitary Hormones Pituitary Hormones, Posterior Reproductive Control Agents Tocolytic Agents
Cross-references: BindingDB: 50177595 ChEBI: 135899 CHEMBL382301 ChemSpider: 4470550 D03008 RxCUI: 59639 Wikipedia: Atosiban ZINC: ZINC000169362009
Target Activities (4)
Target Gene Organism Category Pfam pChEMBL Type Source
P37288 AVPR1A Homo sapiens Human PF00001 PF08983 9.2 Ki ChEMBL
P30559 OXTR Homo sapiens Human PF00001 7.4 Ki ChEMBL;BindingDB
P47901 AVPR1B Homo sapiens Human PF00001 7.4 Ki ChEMBL
P30518 AVPR2 Homo sapiens Human PF00001 6.5 Ki ChEMBL
DrugBank Target Actions (4)
Target Gene Target Name Action Type
P30518 AVPR2 Vasopressin V2 receptor antagonist targets
P30559 OXTR Oxytocin receptor antagonist targets
P37288 AVPR1A Vasopressin V1a receptor antagonist targets
P47901 AVPR1B Vasopressin V1b receptor antagonist targets