Molecule Details
| InChIKey | VWFJDQUYCIWHTN-YFVJMOTDSA-N |
|---|---|
| Compound Name | Farnesyl pyrophosphate |
| Canonical SMILES | CC(C)=CCC/C(C)=C/CC/C(C)=C/COP(=O)(O)OP(=O)(O)O |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.91 |
| Source | ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB07780 |
|---|---|
| Drug Name | Farnesyl diphosphate |
| CAS Number | 13058-04-3 |
| Groups | experimental |
| ATC Codes | nan |
| Description | nan |
Categories: Organophosphates Organophosphorus Compounds Potential QTc-Prolonging Agents QTc Prolonging Agents Terpenes
Cross-references: BindingDB: 50366477 ChEBI: 17407 CHEMBL69330 ChemSpider: 393270 C00448 PDB: FPP PubChem:445713 PubChem:99444251 Wikipedia: Farnesyl_pyrophosphate ZINC: ZINC000012494625
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P49354 | FNTA | Homo sapiens | Human | PF01239 | 8.7 | Kd | ChEMBL |
| P49356 | FNTB | Homo sapiens | Human | PF00432 | 8.7 | Kd | ChEMBL |
| P22007 | RAM1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Pathogen | PF00432 | 7.1 | Kd | ChEMBL |
| P29703 | RAM2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Pathogen | PF01239 | 7.1 | Kd | ChEMBL |
DrugBank Target Actions (12)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| O95749 | GGPS1 | Geranylgeranyl pyrophosphate synthase | binder | targets |
| P01116 | KRAS | GTPase KRas | binder | targets |
| P14324 | FDPS | Farnesyl pyrophosphate synthase | binder | targets |
| P29559 | P29559 | Lantibiotic nisin-Z | binder | targets |
| P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | binder | targets |
| P49356 | FNTB | Protein farnesyltransferase subunit beta | binder | targets |
| P53611 | P53611 | Geranylgeranyl transferase type-2 subunit beta | binder | targets |
| P60472 | P60472 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | binder | targets |
| P9WFF5 | P9WFF5 | (2Z,6E)-farnesyl diphosphate synthase | binder | targets |
| Q8EBR3 | Q8EBR3 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | binder | targets |
| Q92696 | Q92696 | Geranylgeranyl transferase type-2 subunit alpha | binder | targets |
| P37268 | FDFT1 | Squalene synthase | modulator | targets |