N-[3-(dimethylamino)propyl]-9-(4-hydroxy-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepine-3-carboxamide

InChIKey	`VWACUNWBMWWMPJ-UHFFFAOYSA-N`
Compound Name	N-[3-(dimethylamino)propyl]-9-(4-hydroxy-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepine-3-carboxamide
Canonical SMILES	`COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCCCN(C)C)cc2NC3=O)ccc1O`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	18
Pfam Stratification	Cross-Family
Avg pChEMBL	6.76
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
Q04771	ACVR1	Homo sapiens	Human	PF01064 PF07714 PF08515	8.5	Ki	ChEMBL
Q00535	CDK5	Homo sapiens	Human	PF00069	8.0	Ki	ChEMBL
O43293	DAPK3	Homo sapiens	Human	PF00069	7.2	Ki	ChEMBL
Q12851	MAP4K2	Homo sapiens	Human	PF00780 PF00069	7.1	Ki	ChEMBL
Q9HAZ1	CLK4	Homo sapiens	Human	PF00069	7.1	Ki	ChEMBL
Q9Y463	DYRK1B	Homo sapiens	Human	PF00069	7.0	Ki	ChEMBL
O14757	CHEK1	Homo sapiens	Human	PF00069	6.8	Ki	ChEMBL
P00519	ABL1	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	6.6	Ki	ChEMBL
Q9UM73	ALK	Homo sapiens	Human	PF12810 PF00629 PF07714	6.6	Ki	ChEMBL
Q13627	DYRK1A	Homo sapiens	Human	PF00069	6.5	Ki	ChEMBL
P06239	LCK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.4	Ki	ChEMBL
P29376	LTK	Homo sapiens	Human	PF12810 PF07714	6.4	Ki	ChEMBL
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	6.3	Ki	ChEMBL
P50750	CDK9	Homo sapiens	Human	PF00069	6.3	Ki	ChEMBL
O96013	PAK4	Homo sapiens	Human	PF00786 PF00069	6.2	Ki	ChEMBL
P07949	RET	Homo sapiens	Human	PF00028 PF07714 PF17756 PF17812 PF17813 PF22540	6.2	Ki	ChEMBL
P16234	PDGFRA	Homo sapiens	Human	PF07679 PF25305 PF07714	6.2	Ki	ChEMBL
P45983	MAPK8	Homo sapiens	Human	PF00069	6.2	Ki	ChEMBL