Molecule Details
| InChIKey | VTTONGPRPXSUTJ-UHFFFAOYSA-N |
|---|---|
| Compound Name | Bufotenine |
| Canonical SMILES | CN(C)CCc1c[nH]c2ccc(O)cc12 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.66 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01445 |
|---|---|
| Drug Name | Bufotenine |
| CAS Number | 487-93-4 |
| Groups | experimental illicit |
| ATC Codes | nan |
| Description | A hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a tool in CNS studies and misused as a psychedelic. |
Categories: Amphibian Venoms Antidepressive Agents Biological Factors Central Nervous System Agents Central Nervous System Depressants Complex Mixtures Hallucinogens Heterocyclic Compounds, Fused-Ring Indoles Monoamine Oxidase A Substrates N,N-Dimethyltryptamine Neurotransmitter Agents Psychotropic Drugs Serotonin 5-HT1 Receptor Antagonists Serotonin 5-HT1D Receptor Antagonists Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin Agents Serotonin Receptor Antagonists Toxins, Biological Tryptamines Venoms
Cross-references: BindingDB: 50024206 ChEBI: 3210 CHEMBL416526 ChemSpider: 9839 Guide to Pharmacology: 144 IUPHAR: 144 C08299 PubChem:10257 PubChem:46507174 Wikipedia: Bufotenin ZINC: ZINC000000001070
Target Activities (3)
DrugBank Target Actions (6)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P21397 | MAOA | Amine oxidase [flavin-containing] A | substrate | enzymes |
| P34969 | HTR7 | 5-hydroxytryptamine receptor 7 | agonist | targets |
| P28221 | HTR1D | 5-hydroxytryptamine receptor 1D | antagonist | targets |
| P28223 | HTR2A | 5-hydroxytryptamine receptor 2A | antagonist | targets |
| P47898 | HTR5A | 5-hydroxytryptamine receptor 5A | antagonist | targets |
| P50406 | HTR6 | 5-hydroxytryptamine receptor 6 | antagonist | targets |