InChIKey	VSWBSWWIRNCQIJ-UHFFFAOYSA-N
Compound Name	5-Chloro-2-methyl-2,3,3a,12b-tetrahydrodibenzo(2,3:6,7)oxepino(4,5-c)pyrrole
Canonical SMILES	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	23
Pfam Stratification	Cross-Family
Avg pChEMBL	8.27
Source	BindingDB;ChEMBL

DrugBank ID	DB06216
Drug Name	Asenapine
CAS Number	65576-45-6
Groups	approved investigational
ATC Codes	N05AH05
Description	Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine also belongs to the dibenzo-oxepino pyrrole class. It is also for seve...

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Categories: Acid Reducers Adrenergic Antagonists Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Agents that produce hypertension Antidepressive Agents Antipsychotic Agents Antipsychotic Agents (Second Generation [Atypical]) Benzocycloheptenes Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Diazepines, Oxazepines, Thiazepines and Oxepines Dopamine Antagonists Dopamine D2 Receptor Antagonists Heterocyclic Compounds, Fused-Ring Highest Risk QTc-Prolonging Agents Histamine Antagonists Histamine H1 Antagonists Histamine H2 Antagonists Hyperglycemia-Associated Agents Nervous System Neurotoxic agents Psycholeptics Psychotropic Drugs QTc Prolonging Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin 5-HT1 Receptor Antagonists Serotonin 5-HT1A Receptor Antagonists Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin 5-HT2C Receptor Antagonists Serotonin Agents Serotonin Receptor Agonists Serotonin Receptor Antagonists Tranquilizing Agents UGT1A4 substrates

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Cross-references: ChEBI: 71255 CHEMBL3187365 ChemSpider: 8079624 Drugs Product Database (DPD): 21015 D02995 PubChem:11954293 PubChem:175427062 RxCUI: 784649 Wikipedia: Asenapine ZINC: ZINC000000002299