InChIKey	VRBKIVRKKCLPHA-UHFFFAOYSA-N
Compound Name	Nefazodone
Canonical SMILES	CCc1nn(CCCN2CCN(c3cccc(Cl)c3)CC2)c(=O)n1CCOc1ccccc1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	22
Pfam Stratification	Cross-Family
Avg pChEMBL	6.71
Source	BindingDB;ChEMBL

DrugBank ID	DB01149
Drug Name	Nefazodone
CAS Number	83366-66-9
Groups	approved withdrawn
ATC Codes	N06AX06
Description	Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liv...

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Categories: Adrenergic Antagonists Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Agents that produce hypertension Analgesics Antidepressive Agents Antidepressive Agents Indicated for Depression Antidepressive Agents, Second-Generation Antidepressive Agents, Triazolopyridine BSEP/ABCB11 Substrates Central Nervous System Agents Central Nervous System Depressants Combined Inhibitors of Serotonin/Norepinephrine Reuptake Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strong) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs that are Mainly Renally Excreted Hypoglycemia-Associated Agents Membrane Transport Modulators Nervous System Neurotransmitter Agents Neurotransmitter Uptake Inhibitors OATP1B3 inhibitors Organic Anion Transporting Polypeptide 2B1 Inhibitors P-glycoprotein inducers P-glycoprotein inhibitors Psychoanaleptics Psychotropic Drugs Selective Serotonin Reuptake Inhibitors Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin 5-HT1 Receptor Antagonists Serotonin 5-HT1A Receptor Antagonists Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin 5-HT2C Receptor Antagonists Serotonin Agents Serotonin Modulators Serotonin Receptor Antagonists Serotonin and Noradrenaline Reuptake Inhibitors Serotonin antagonist and reuptake inhibitors (SARIs)

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Cross-references: BindingDB: 50069447 ChEBI: 7494 CHEMBL623 ChemSpider: 4294 Drugs Product Database (DPD): 449 C07256 D08257 PharmGKB: PA450603 PubChem:4449 PubChem:46508323 RxCUI: 31565 Therapeutic Targets Database: DAP000042 Wikipedia: Nefazodone ZINC: ZINC000000538065