Molecule Details
| InChIKey | VQZOVNXFKLFYIO-UHFFFAOYSA-N |
|---|---|
| Compound Name | 2,2,2-trifluoro-1-[7-[[2-(3-fluoroanilino)-5-[1-(2-hydroxyethyl)pyrazol-4-yl]pyrimidin-4-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]ethanone |
| Canonical SMILES | O=C(N1CCc2ccc(Nc3nc(Nc4cccc(F)c4)ncc3-c3cnn(CCO)c3)cc2C1)C(F)(F)F |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.27 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q06418 | TYRO3 | Homo sapiens | Human | PF00041 PF07679 PF07714 | 7.8 | IC50 | ChEMBL;BindingDB |
| Q12866 | MERTK | Homo sapiens | Human | PF00041 PF00047 PF13927 PF07714 | 7.6 | IC50 | ChEMBL;BindingDB |
| P30530 | AXL | Homo sapiens | Human | PF00041 PF13927 PF07714 | 6.4 | IC50 | ChEMBL;BindingDB |