1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea

InChIKey	`VQPBIJGXSXEOCU-UHFFFAOYSA-N`
Compound Name	1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
Canonical SMILES	`COc1ccc2c(NC(=O)Nc3cccc(C(F)(F)F)n3)ccnc2c1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	24
Pfam Stratification	Cross-Family
Avg pChEMBL	6.72
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
Q13882	PTK6	Homo sapiens	Human	PF07714 PF00017 PF00018	7.8	Ki	ChEMBL
Q9HAZ1	CLK4	Homo sapiens	Human	PF00069	7.6	Ki	ChEMBL
Q8NE63	HIPK4	Homo sapiens	Human	PF00069	7.3	Ki	ChEMBL
Q9H2X6	HIPK2	Homo sapiens	Human	PF00069	7.3	Ki	ChEMBL
O95819	MAP4K4	Homo sapiens	Human	PF00780 PF00069	7.2	Ki	ChEMBL
P08922	ROS1	Homo sapiens	Human	PF00041 PF07714	7.2	Ki	ChEMBL
P07949	RET	Homo sapiens	Human	PF00028 PF07714 PF17756 PF17812 PF17813 PF22540	7.0	Ki	ChEMBL
P24941	CDK2	Homo sapiens	Human	PF00069	7.0	Ki	ChEMBL
P49760	CLK2	Homo sapiens	Human	PF00069	7.0	Ki	ChEMBL
P17948	FLT1	Homo sapiens	Human	PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	6.9	Ki	ChEMBL
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	6.9	Ki	ChEMBL
Q86V86	PIM3	Homo sapiens	Human	PF00069	6.9	Ki	ChEMBL
Q96GD4	AURKB	Homo sapiens	Human	PF00069	6.8	Ki	ChEMBL
Q13627	DYRK1A	Homo sapiens	Human	PF00069	6.6	Ki	ChEMBL
Q9H2G2	SLK	Homo sapiens	Human	PF00069 PF12474	6.4	Ki	ChEMBL
Q13188	STK3	Homo sapiens	Human	PF11629 PF00069	6.3	Ki	ChEMBL
Q9UEE5	STK17A	Homo sapiens	Human	PF00069	6.3	Ki	ChEMBL
O43781	DYRK3	Homo sapiens	Human	PF00069	6.2	Ki	ChEMBL
P06493	CDK1	Homo sapiens	Human	PF00069	6.2	Ki	ChEMBL
Q04771	ACVR1	Homo sapiens	Human	PF01064 PF07714 PF08515	6.2	Ki	ChEMBL
P22607	FGFR3	Homo sapiens	Human	PF21165 PF07679 PF13927 PF07714	6.1	Ki	ChEMBL
P43405	SYK	Homo sapiens	Human	PF07714 PF00017	6.1	Ki	ChEMBL
O00444	PLK4	Homo sapiens	Human	PF00069 PF18190 PF18409	6.0	Ki	ChEMBL
P16591	FER	Homo sapiens	Human	PF00611 PF07714 PF00017	6.0	Ki	ChEMBL