Molecule Details
| InChIKey | VQINULODWGEVBB-UHFFFAOYSA-N |
|---|---|
| Compound Name | 3-(2-chloro-6-methylphenyl)-7-(2-methoxy-4-(1-methylpiperidin-4-yl)anilino)-1-(5-methoxypyridin-2-yl)-4H-pyrimido(4,5-d)pyrimidin-2-one |
| Canonical SMILES | COc1ccc(N2C(=O)N(c3c(C)cccc3Cl)Cc3cnc(Nc4ccc(C5CCN(C)CC5)cc4OC)nc32)nc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.96 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P07333 | CSF1R | Homo sapiens | Human | PF00047 PF25305 PF07714 | 8.9 | IC50 | ChEMBL |
| P57059 | SIK1 | Homo sapiens | Human | PF00069 PF23312 | 8.0 | IC50 | ChEMBL |
| Q9Y2K2 | SIK3 | Homo sapiens | Human | PF00069 PF23312 | 7.5 | IC50 | ChEMBL |
| Q9H0K1 | SIK2 | Homo sapiens | Human | PF00069 PF23312 | 7.4 | IC50 | BindingDB |