Molecule Details
| InChIKey | VPFQXVNSENBLHV-LSDHHAIUSA-N |
|---|---|
| Compound Name | 6-[[(3R,4R)-3-aminooxan-4-yl]amino]-8-(1H-indol-7-ylamino)-2H-2,7-naphthyridin-1-one |
| Canonical SMILES | N[C@H]1COCC[C@H]1Nc1cc2cc[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.9 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P36888 | FLT3 | Homo sapiens | Human | PF00047 PF07714 | 7.7 | IC50 | ChEMBL;BindingDB |
| P43405 | SYK | Homo sapiens | Human | PF07714 PF00017 | 7.3 | IC50 | ChEMBL;BindingDB |
| P43403 | ZAP70 | Homo sapiens | Human | PF07714 PF00017 | 6.5 | IC50 | ChEMBL;BindingDB |
| O60674 | JAK2 | Homo sapiens | Human | PF18379 PF18377 PF17887 PF07714 PF21990 | 6.2 | IC50 | ChEMBL;BindingDB |