Molecule Details
InChIKeyVOKSWYLNZZRQPF-UHFFFAOYSA-N
Compound NameTalwin
Canonical SMILESCC(C)=CCN1CCC2(C)c3cc(O)ccc3CC1C2C
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)4
Pfam Stratification Cross-Family
Avg pChEMBL8.04
SourceChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00652
Drug NamePentazocine
CAS Number359-83-1
Groups approved vet_approved
ATC Codes N02AD51 N02AD01
DescriptionThe first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)

Categories: Adjuvants, Anesthesia Agents that reduce seizure threshold Alkaloids Analgesics Benzomorphan Derivatives Benzomorphans Central Nervous System Agents Central Nervous System Depressants Heterocyclic Compounds, Fused-Ring Mixed Agonist / Antagonist Opioids Morphinans Narcotics Nervous System Opiate Alkaloids Opiate Partial Agonists Opioid Antagonists Opioids P-glycoprotein substrates Partial Opioid Agonist/Antagonist Peripheral Nervous System Agents Phenanthrenes Sensory System Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
Cross-references: BindingDB: 50032403 ChEBI: 182080 CHEMBL100116 ChemSpider: 4574 Drugs Product Database (DPD): 9401 Guide to Pharmacology: 1606 IUPHAR: 1606 C07421 D00498 PharmGKB: PA164744326 PubChem:441278 PubChem:46506363 RxCUI: 8001 Therapeutic Targets Database: DAP000356 Wikipedia: Pentazocine ZINC: ZINC000000000596
Target Activities (4)
Target Gene Organism Category Pfam pChEMBL Type Source
P35372 OPRM1 Homo sapiens Human PF00001 8.4 Ki ChEMBL
P41145 OPRK1 Homo sapiens Human PF00001 8.4 Ki ChEMBL
Q99720 SIGMAR1 Homo sapiens Human PF04622 8.1 Ki ChEMBL
P41143 OPRD1 Homo sapiens Human PF00001 7.2 Ki ChEMBL
DrugBank Target Actions (4)
Target Gene Target Name Action Type
P41145 OPRK1 Kappa-type opioid receptor agonist targets
Q99720 SIGMAR1 Sigma non-opioid intracellular receptor 1 agonist targets
P35372 OPRM1 Mu-type opioid receptor antagonist targets
P08183 ABCB1 ATP-dependent translocase ABCB1 substrate transporters