Molecule Details
| InChIKey | VNWKVRSLWCIUCC-UHFFFAOYSA-N |
|---|---|
| Compound Name | Pde5-IN-2 |
| Canonical SMILES | COCCNc1cc(O)c2c(=O)c3c(-c4nccs4)[nH]c(Cc4ccc5c(c4)OCO5)c3oc2c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 7 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.77 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (7)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O76074 | PDE5A | Homo sapiens | Human | PF01590 PF00233 | 9.5 | IC50 | ChEMBL;BindingDB |
| P51160 | PDE6C | Homo sapiens | Human | PF01590 PF00233 | 8.9 | IC50 | ChEMBL;BindingDB |
| Q9HCR9 | PDE11A | Homo sapiens | Human | PF01590 PF00233 | 7.4 | IC50 | ChEMBL;BindingDB |
| Q08499 | PDE4D | Homo sapiens | Human | PF18100 PF00233 | 7.4 | IC50 | ChEMBL;BindingDB |
| Q9Y233 | PDE10A | Homo sapiens | Human | PF01590 PF00233 | 7.3 | IC50 | ChEMBL;BindingDB |
| O00408 | PDE2A | Homo sapiens | Human | PF01590 PF00233 | 7.0 | IC50 | ChEMBL;BindingDB |
| P11712 | CYP2C9 | Homo sapiens | Human | PF00067 | 6.9 | IC50 | ChEMBL;BindingDB |