InChIKey	VKQFCGNPDRICFG-UHFFFAOYSA-N
Compound Name	Nisoldipine
Canonical SMILES	COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-]
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Cross-Family
Avg pChEMBL	7.26
Source	ChEMBL;BindingDB

DrugBank ID	DB00401
Drug Name	Nisoldipine
CAS Number	63675-72-9
Groups	approved
ATC Codes	C08CA07
Description	Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smoo...

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Categories: Agents causing hyperkalemia Antiarrhythmic agents Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension Bradycardia-Causing Agents Calcium Channel Blockers Calcium Channel Blockers (Dihydropyridine) Calcium-Regulating Hormones and Agents Cardiovascular Agents Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Substrates Decreased Blood Pressure Dihydropyridine Derivatives Dihydropyridines Drugs causing inadvertant photosensitivity Drugs that are Mainly Renally Excreted Hypotensive Agents Membrane Transport Modulators P-glycoprotein inhibitors Photosensitizing Agents Pyridines Selective Calcium Channel Blockers With Mainly Vascular Effects Vasodilating Agents

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Cross-references: BindingDB: 642532 ChEBI: 76917 CHEMBL1726 ChemSpider: 4343 Guide to Pharmacology: 2524 IUPHAR: 2524 C07699 D00618 PharmGKB: PA450634 PubChem:4499 PubChem:46504546 RxCUI: 7435 Therapeutic Targets Database: DAP000595 Wikipedia: Nisoldipine