InChIKey	VIKNJXKGJWUCNN-XGXHKTLJSA-N
Compound Name	Norethindrone
Canonical SMILES	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	6
Pfam Stratification	Cross-Family
Avg pChEMBL	7.15
Source	ChEMBL;BindingDB;TTD_MultiTarget

DrugBank ID	DB00717
Drug Name	Norethisterone
CAS Number	68-22-4
Groups	approved investigational
ATC Codes	H01CC53 H01CC54 G03AA05 G03DC02 G03AB04 G03AC01 G03FA01 G03FB05
Description	Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins.[A10367] It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several ot...

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Categories: Adrenal Cortex Hormones Anti-Gonadotropin-Releasing Hormones Combination Contraceptives (with Estrogen and derivatives) Contraceptive Agents, Female Contraceptive Agents, Hormonal Contraceptives, Oral Contraceptives, Oral, Hormonal Contraceptives, Oral, Synthetic Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2A6 Substrates Cytochrome P-450 CYP2C19 Inducers Cytochrome P-450 CYP2C19 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates (strength unknown) Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Substrates Estren Derivatives Fused-Ring Compounds Genito Urinary System and Sex Hormones Hormonal Contraceptives for Systemic Use Hyperglycemia-Associated Agents Hypothalamic Hormones Norpregnenes Norsteroids P-glycoprotein inhibitors Pituitary and Hypothalamic Hormones and Analogues Progestin Contraceptives Progestins Progestogens and Estrogens, Sequential Preparations Reproductive Control Agents Sex Hormones and Modulators of the Genital System Steroids Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins

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Cross-references: BindingDB: 50148732 ChEBI: 7627 CHEMBL1162 ChemSpider: 5994 Drugs Product Database (DPD): 7500 C05028 D00182 PDB: NDR PharmGKB: PA450651 PubChem:6230 PubChem:46504816 RxCUI: 7514 Therapeutic Targets Database: DAP001212 Wikipedia: Norethisterone ZINC: ZINC000085205451