Molecule Details
| InChIKey | VHFVKMTVMIZMIK-UHFFFAOYSA-N |
|---|---|
| Compound Name | 1-(3-Chlorophenyl)piperazine |
| Canonical SMILES | Clc1cccc(N2CCNCC2)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 15 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.04 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB12110 |
|---|---|
| Drug Name | m-Chlorophenylpiperazine |
| CAS Number | 6640-24-0 |
| Groups | investigational |
| ATC Codes | nan |
| Description | m-Chlorophenylpiperazine has been used in trials studying the treatment of Alcoholism. |
Categories: Antidepressive Agents Central Nervous System Depressants Neurotransmitter Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin 5-HT1 Receptor Antagonists Serotonin 5-HT1D Receptor Antagonists Serotonin 5-HT2 Receptor Agonists Serotonin Agents Serotonin Receptor Agonists Serotonin Receptor Antagonists
Cross-references: BindingDB: 50001915 ChEBI: 10588 CHEMBL478 ChemSpider: 1314 C11738 PubChem:1355 PubChem:347828411 ZINC: ZINC000000004285
Target Activities (15)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P28335 | HTR2C | Homo sapiens | Human | PF00001 | 7.8 | Ki | ChEMBL;BindingDB |
| P41595 | HTR2B | Homo sapiens | Human | PF00001 | 7.5 | Ki | ChEMBL;BindingDB |
| P28223 | HTR2A | Homo sapiens | Human | PF00001 | 7.3 | Ki | ChEMBL;BindingDB |
| A5X5Y0 | HTR3E | Homo sapiens | Human | PF02931 PF02932 | 7.2 | Ki | ChEMBL |
| O95264 | HTR3B | Homo sapiens | Human | PF02931 PF02932 | 7.2 | Ki | ChEMBL |
| P46098 | HTR3A | Homo sapiens | Human | PF02931 PF02932 | 7.2 | Ki | ChEMBL;BindingDB |
| Q70Z44 | HTR3D | Homo sapiens | Human | PF02931 PF02932 | 7.2 | Ki | ChEMBL |
| Q8WXA8 | HTR3C | Homo sapiens | Human | PF02931 PF02932 | 7.2 | Ki | ChEMBL |
| P35348 | ADRA1A | Homo sapiens | Human | PF00001 | 7.0 | Ki | BindingDB |
| P08908 | HTR1A | Homo sapiens | Human | PF00001 | 7.0 | Ki | ChEMBL;BindingDB |
| P28222 | HTR1B | Homo sapiens | Human | PF00001 | 6.7 | Ki | BindingDB |
| P08913 | ADRA2A | Homo sapiens | Human | PF00001 | 6.6 | Ki | BindingDB |
| P31645 | SLC6A4 | Homo sapiens | Human | PF03491 PF00209 | 6.6 | Ki | ChEMBL;BindingDB |
| P28221 | HTR1D | Homo sapiens | Human | PF00001 | 6.6 | Ki | BindingDB |
| P34969 | HTR7 | Homo sapiens | Human | PF00001 | 6.5 | Ki | ChEMBL;BindingDB |
DrugBank Target Actions (7)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P28223 | HTR2A | 5-hydroxytryptamine receptor 2A | agonist | targets |
| P28335 | HTR2C | 5-hydroxytryptamine receptor 2C | agonist | targets |
| P28566 | HTR1E | 5-hydroxytryptamine receptor 1E | agonist | targets |
| P34969 | HTR7 | 5-hydroxytryptamine receptor 7 | agonist | targets |
| P41595 | HTR2B | 5-hydroxytryptamine receptor 2B | agonist | targets |
| P50406 | HTR6 | 5-hydroxytryptamine receptor 6 | agonist | targets |
| P28221 | HTR1D | 5-hydroxytryptamine receptor 1D | antagonist | targets |