InChIKey	VGKDLMBJGBXTGI-SJCJKPOMSA-N
Compound Name	Sertraline
Canonical SMILES	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	15
Pfam Stratification	Cross-Family
Avg pChEMBL	6.7
Source	ChEMBL;BindingDB

DrugBank ID	DB01104
Drug Name	Sertraline
CAS Number	79617-96-2
Groups	approved investigational
ATC Codes	N06AB06
Description	Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects....

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Categories: Agents that reduce seizure threshold Amines Antidepressive Agents Antidepressive Agents Indicated for Depression Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strength unknown) Cytochrome P-450 CYP2B6 Substrates Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (moderate) Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2E1 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs causing inadvertant photosensitivity Hypoglycemia-Associated Agents Membrane Transport Modulators Monoamine Oxidase A Substrates Naphthalenes Nervous System Neurotransmitter Agents Neurotransmitter Uptake Inhibitors P-glycoprotein inhibitors Photosensitizing Agents Psychoanaleptics Psychotropic Drugs QTc Prolonging Agents Selective Serotonin Reuptake Inhibitors Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin Agents Serotonin Modulators

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Cross-references: BindingDB: 86421 ChEBI: 9123 CHEMBL809 ChemSpider: 61881 Drugs Product Database (DPD): 11168 C07246 D02360 PDB: SRE PharmGKB: PA451333 PubChem:68617 PubChem:46505341 RxCUI: 36437 Therapeutic Targets Database: DAP000051 Wikipedia: Sertraline ZINC: ZINC000001853550