InChIKey	VFCRKLWBYMDAED-REWPJTCUSA-N
Compound Name	Nirogacestat
Canonical SMILES	CCC[C@H](N[C@H]1CCc2cc(F)cc(F)c2C1)C(=O)Nc1cn(C(C)(C)CNCC(C)(C)C)cn1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	7
Pfam Stratification	Cross-Family
Avg pChEMBL	8.21
Source	ChEMBL;BindingDB

DrugBank ID	DB12005
Drug Name	Nirogacestat
CAS Number	1290543-63-3
Groups	approved investigational
ATC Codes	L01XX81
Description	Nirogacestat is a small-molecule gamma-secretase inhibitor that was investigated as a potential treatment for desmoid tumors. Desmoid tumors are typically characterized by aberrant activation in Notch signaling.[A262556] Interaction between the notch receptors and their ligands activates proteolytic...

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Categories: Amino Acids Amino Acids, Branched-Chain Amino Acids, Peptides, and Proteins Amyloid Precursor Protein Secretases, antagonists & inhibitors Antineoplastic Agents Antineoplastic and Immunomodulating Agents Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inducers Cytochrome P-450 CYP2C19 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C8 Inducers Cytochrome P-450 CYP2C8 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Substrates Enzyme Inhibitors Gamma Secretase Inhibitor Gamma Secretase Inhibitors and Modulators P-glycoprotein inhibitors P-glycoprotein substrates

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Cross-references: BindingDB: 50458159 CHEMBL1770916 ChemSpider: 26232306 PDB: O6U PubChem:46224413 PubChem:347828323 RxCUI: 2670631 Wikipedia: Nirogacestat ZINC: ZINC000038217837