Molecule Details
InChIKeyVDXGLZJPQRGNLY-UHFFFAOYSA-N
Compound NameMulti-kinase-IN-6
Canonical SMILESCOc1ccc(-c2ccnc3c(-c4noc(C)n4)c(C)nn23)cc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)10
Pfam Stratification Cross-Family
Avg pChEMBL6.69
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (10)
Target Gene Organism Category Pfam pChEMBL Type Source
Q04771 ACVR1 Homo sapiens Human PF01064 PF07714 PF08515 7.4 IC50 ChEMBL
P10721 KIT Homo sapiens Human PF00047 PF07714 7.2 IC50 ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 7.0 IC50 ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 7.0 IC50 ChEMBL
O14757 CHEK1 Homo sapiens Human PF00069 6.8 IC50 ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.5 IC50 ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.4 IC50 ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.3 IC50 ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.2 IC50 ChEMBL
P08922 ROS1 Homo sapiens Human PF00041 PF07714 6.1 IC50 ChEMBL