Molecule Details
| InChIKey | VCZDFACOFNRTMG-UHFFFAOYSA-N |
|---|---|
| Compound Name | 8-(4-Aminobutyl)-6-(2,5-difluorophenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one |
| Canonical SMILES | CNc1ncc2cc(-c3cc(F)ccc3F)c(=O)n(CCCCN)c2n1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 6 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.87 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (6)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q9Y2K2 | SIK3 | Homo sapiens | Human | PF00069 PF23312 | 7.8 | IC50 | ChEMBL |
| P57059 | SIK1 | Homo sapiens | Human | PF00069 PF23312 | 7.1 | IC50 | ChEMBL |
| Q9H0K1 | SIK2 | Homo sapiens | Human | PF00069 PF23312 | 7.0 | IC50 | ChEMBL |
| P21709 | EPHA1 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 | 6.8 | IC50 | ChEMBL |
| P54760 | EPHB4 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 | 6.2 | IC50 | ChEMBL |
| P54762 | EPHB1 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 | 6.2 | IC50 | ChEMBL |