Molecule Details
InChIKeyVCSQVKQFGYRGEH-UHFFFAOYSA-N
Compound Name1-(3,4-dimethylphenyl)-3-[4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl]urea
Canonical SMILESCc1ccc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)cc2)cc1C
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)13
Pfam Stratification Cross-Family
Avg pChEMBL6.74
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (13)
Target Gene Organism Category Pfam pChEMBL Type Source
Q96GD4 AURKB Homo sapiens Human PF00069 7.8 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.7 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.3 IC50 ChEMBL;BindingDB
Q9H2X6 HIPK2 Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 7.1 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 7.1 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 6.7 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.4 Ki ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 6.2 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.1 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.0 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 6.0 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.0 Ki ChEMBL