4-[4-(2-fluoro-4-isocyanobenzoyl)piperazin-1-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]butanenitrile

InChIKey	`VCJFOLMEZCAWFO-UHFFFAOYSA-N`
Compound Name	4-[4-(2-fluoro-4-isocyanobenzoyl)piperazin-1-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]butanenitrile
Canonical SMILES	`[C-]#[N+]c1ccc(C(=O)N2CCN(CC(CC#N)n3cc(-c4ncnc5[nH]ccc45)cn3)CC2)c(F)c1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Homologous
Avg pChEMBL	6.52
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P30530	AXL	Homo sapiens	Human	PF00041 PF13927 PF07714	6.5	IC50	ChEMBL
Q06418	TYRO3	Homo sapiens	Human	PF00041 PF07679 PF07714	6.5	IC50	ChEMBL
Q12866	MERTK	Homo sapiens	Human	PF00041 PF00047 PF13927 PF07714	6.5	IC50	ChEMBL