Molecule Details
InChIKeyVBGLYOIFKLUMQG-UHFFFAOYSA-N
Compound NameCannabinol
Canonical SMILESCCCCCc1cc(O)c2c(c1)OC(C)(C)c1ccc(C)cc1-2
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)7
Pfam Stratification Cross-Family
Avg pChEMBL6.7
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB14737
Drug NameCannabinol
CAS Number521-35-7
Groups investigational
ATC Codes nan
DescriptionCannabinol (CBN) is a physiologically inactive constituent of Cannabis sativa.

Categories: BCRP/ABCG2 Inhibitors Cannabinoids and similars Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strength unknown) Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strength unknown) Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Inhibitors (weak) Cytochrome P-450 CYP3A7 Inhibitors Cytochrome P-450 CYP3A7 Inhibitors (weak) Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates P-glycoprotein inhibitors Terpenes UGT1A9 Inhibitors UGT1A9 Substrates UGT2B7 inducers UGT2B7 substrates
Cross-references: BindingDB: 50061117 ChEBI: 3360 CHEMBL74415 ChemSpider: 2447 C07580 RxCUI: 1976 Wikipedia: Cannabinol ZINC: ZINC000001530833
Target Activities (7)
Target Gene Organism Category Pfam pChEMBL Type Source
P21554 CNR1 Homo sapiens Human PF00001 7.2 Ki ChEMBL;BindingDB
P05177 CYP1A2 Homo sapiens Human PF00067 7.1 Ki ChEMBL;BindingDB
P34972 CNR2 Homo sapiens Human PF00001 7.0 Ki ChEMBL;BindingDB
Q16678 CYP1B1 Homo sapiens Human PF00067 6.8 Ki ChEMBL;BindingDB
O75762 TRPA1 Homo sapiens Human PF00023 PF12796 PF13637 PF00520 6.5 IC50 ChEMBL;BindingDB
P04798 CYP1A1 Homo sapiens Human PF00067 6.3 Ki ChEMBL;BindingDB
P11509 CYP2A6 Homo sapiens Human PF00067 6.0 Ki ChEMBL;BindingDB
DrugBank Target Actions (29)
Target Gene Target Name Action Type
P16662 UGT2B7 UDP-glucuronosyltransferase 2B7 inducer enzymes
O60656 O60656 UDP-glucuronosyltransferase 1A9 inhibitor enzymes
P04798 CYP1A1 Cytochrome P450 1A1 inhibitor enzymes
P05177 CYP1A2 Cytochrome P450 1A2 inhibitor enzymes
P05181 CYP2E1 Cytochrome P450 2E1 inhibitor enzymes
P08684 CYP3A4 Cytochrome P450 3A4 inhibitor enzymes
P10635 CYP2D6 Cytochrome P450 2D6 inhibitor enzymes
P11509 CYP2A6 Cytochrome P450 2A6 inhibitor enzymes
P11712 CYP2C9 Cytochrome P450 2C9 inhibitor enzymes
P20813 CYP2B6 Cytochrome P450 2B6 inhibitor enzymes
P20815 CYP3A5 Cytochrome P450 3A5 inhibitor enzymes
P23141 CES1 Liver carboxylesterase 1 inhibitor enzymes
P24462 CYP3A7 Cytochrome P450 3A7 inhibitor enzymes
P51589 CYP2J2 Cytochrome P450 2J2 inhibitor enzymes
Q16678 CYP1B1 Cytochrome P450 1B1 inhibitor enzymes
Q9HAW7 Q9HAW7 UDP-glucuronosyltransferase 1A7 inhibitor enzymes
Q9HAW9 Q9HAW9 UDP-glucuronosyltransferase 1A8 inhibitor enzymes
O60656 O60656 UDP-glucuronosyltransferase 1A9 substrate enzymes
P08684 CYP3A4 Cytochrome P450 3A4 substrate enzymes
P11712 CYP2C9 Cytochrome P450 2C9 substrate enzymes
P16662 UGT2B7 UDP-glucuronosyltransferase 2B7 substrate enzymes
P33261 CYP2C19 Cytochrome P450 2C19 substrate enzymes
Q9HAW7 Q9HAW7 UDP-glucuronosyltransferase 1A7 substrate enzymes
Q9HAW8 Q9HAW8 UDP-glucuronosyltransferase 1A10 substrate enzymes
Q9HAW9 Q9HAW9 UDP-glucuronosyltransferase 1A8 substrate enzymes
P21554 CNR1 Cannabinoid receptor 1 agonist targets
P08183 ABCB1 ATP-dependent translocase ABCB1 inhibitor transporters
P33527 ABCC1 Multidrug resistance-associated protein 1 inhibitor transporters
Q9UNQ0 ABCG2 Broad substrate specificity ATP-binding cassette transporter ABCG2 inhibitor transporters