Molecule Details
InChIKeyVAIOZOCLKVMIMN-PRJWTAEASA-N
Compound NameEplivanserin
Canonical SMILESCN(C)CCO/N=C(/C=C/c1ccc(O)cc1)c1ccccc1F
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL8.92
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB12177
Drug NameEplivanserin
CAS Number130579-75-8
Groups investigational
ATC Codes nan
DescriptionEplivanserin has been used in trials studying the treatment of Sleep, Insomnia, Chronic Pain, Fibromyalgia, and Primary Insomnia, among others.

Categories: Antidepressive Agents Benzene Derivatives Cardiovascular Agents Central Nervous System Depressants Fibrin Modulating Agents Hematologic Agents Hydrocarbons, Fluorinated Hydrocarbons, Halogenated Neurotransmitter Agents Serotonin Agents Serotonin Receptor Antagonists
Cross-references: CHEMBL257704 ChemSpider: 13267837 PubChem:5486684 PubChem:347828464 Wikipedia: Eplivanserin ZINC: ZINC000001886642
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P28223 HTR2A Homo sapiens Human PF00001 8.9 Kd ChEMBL;BindingDB
P28335 HTR2C Homo sapiens Human PF00001 8.9 Kd ChEMBL
P41595 HTR2B Homo sapiens Human PF00001 8.9 Kd ChEMBL
DrugBank Target Actions (2)
Target Gene Target Name Action Type
P28223 HTR2A 5-hydroxytryptamine receptor 2A binder targets
P28335 HTR2C 5-hydroxytryptamine receptor 2C binder targets