InChIKey	UZHSEJADLWPNLE-GRGSLBFTSA-N
Compound Name	Naloxone
Canonical SMILES	C=CCN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C5
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Homologous
Avg pChEMBL	7.89
Source	BindingDB;ChEMBL

DrugBank ID	DB01183
Drug Name	Naloxone
CAS Number	465-65-6
Groups	approved investigational vet_approved
ATC Codes	A06AH04 N02AA53 N02AD51 V03AB15 N02AA55 N02AX51
Description	Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide.[A234594] More specifically, naloxone has a high affinity for μ-opioid receptors, where it...

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Categories: Alimentary Tract and Metabolism Alkaloids Analgesics Antidotes Benzomorphan Derivatives Central Nervous System Agents Cytochrome P-450 CYP2C18 Substrates Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs for Constipation Drugs that are Mainly Renally Excreted Heterocyclic Compounds, Fused-Ring Morphinans Natural Opium Alkaloids Nervous System Opiate Alkaloids Opiate Antagonists Opioid Antagonists P-glycoprotein substrates Peripheral Nervous System Agents Peripheral Opioid Receptor Antagonists Phenanthrenes Sensory System Agents UGT1A1 Substrates

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Cross-references: BindingDB: 579486 ChEBI: 7459 CHEMBL80 ChemSpider: 4447644 Drugs Product Database (DPD): 2474 Guide to Pharmacology: 1676 IUPHAR: 1676 C07252 D08249 PDB: A1APV PharmGKB: PA450586 PubChem:5284596 PubChem:46508816 RxCUI: 7242 Therapeutic Targets Database: DAP000097 Wikipedia: Naloxone ZINC: ZINC000000389747