Molecule Details
| InChIKey | UYJZZVDLGDDTCL-UHFFFAOYSA-N |
|---|---|
| Compound Name | PJ-34 |
| Canonical SMILES | CN(C)CC(=O)Nc1ccc2[nH]c(=O)c3ccccc3c2c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 8 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.92 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB08348 |
|---|---|
| Drug Name | N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE |
| CAS Number | nan |
| Groups | experimental |
| ATC Codes | nan |
| Description | nan |
Cross-references: BindingDB: 27497 CHEMBL372303 ChemSpider: 4692 PDB: P34 PubChem:4858 PubChem:99444819 ZINC: ZINC000000008960
Target Activities (8)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O94759 | TRPM2 | Homo sapiens | Human | PF00520 PF18139 PF25969 PF25508 | 7.6 | IC50 | ChEMBL;BindingDB |
| Q9UGN5 | PARP2 | Homo sapiens | Human | PF00644 PF02877 PF05406 | 7.5 | IC50 | ChEMBL;BindingDB |
| O95271 | TNKS | Homo sapiens | Human | PF00023 PF12796 PF00644 PF07647 | 7.4 | IC50 | ChEMBL;BindingDB |
| Q9H2K2 | TNKS2 | Homo sapiens | Human | PF00023 PF12796 PF13637 PF00644 PF07647 | 7.0 | IC50 | ChEMBL;BindingDB |
| P09874 | PARP1 | Homo sapiens | Human | PF00533 PF21728 PF00644 PF02877 PF05406 PF00645 PF08063 | 7.0 | IC50 | ChEMBL;BindingDB |
| Q9H0J9 | PARP12 | Homo sapiens | Human | PF00644 PF24356 PF02825 PF23466 PF25261 | 6.6 | IC50 | ChEMBL;BindingDB |
| Q9Y6F1 | PARP3 | Homo sapiens | Human | PF00644 PF02877 PF05406 | 6.2 | Kd | ChEMBL;BindingDB |
| Q9UKK3 | PARP4 | Homo sapiens | Human | PF00533 PF00644 PF26156 PF08487 PF00092 PF26166 | 6.1 | IC50 | ChEMBL;BindingDB |
DrugBank Target Actions (6)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P11439 | P11439 | Exotoxin A | binder | targets |
| P13639 | P13639 | Elongation factor 2 | binder | targets |
| Q460N3 | PARP15 | Protein mono-ADP-ribosyltransferase PARP15 | binder | targets |
| Q5EK40 | Q5EK40 | Cholix toxin | binder | targets |
| Q9Y6F1 | PARP3 | Protein mono-ADP-ribosyltransferase PARP3 | binder | targets |
| P09874 | PARP1 | Poly [ADP-ribose] polymerase 1 | inhibitor | targets |