Molecule Details
InChIKeyUYJNQQDJUOUFQJ-UHFFFAOYSA-N
Compound Name2-((5-chloro-2-((2-methoxy-4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide
Canonical SMILESCNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)68
Pfam Stratification Cross-Family
Avg pChEMBL6.81
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB07460
Drug Name2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE
CAS Numbernan
Groups experimental
ATC Codes nan
Descriptionnan
Cross-references: BindingDB: 50334594 ChEBI: 91452 CHEMBL458997 ChemSpider: 8109975 PDB: BI9 PubChem:9934347 PubChem:99443931 ZINC: ZINC000020148986
Target Activities (68)
Target Gene Organism Category Pfam pChEMBL Type Source
Q96RR4 CAMKK2 Homo sapiens Human PF00069 8.9 Ki ChEMBL
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 8.6 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 8.4 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 8.4 IC50 ChEMBL;BindingDB
P08922 ROS1 Homo sapiens Human PF00041 PF07714 8.3 Ki ChEMBL
P53779 MAPK10 Homo sapiens Human PF00069 8.2 IC50 ChEMBL
Q05397 PTK2 Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 8.2 IC50 ChEMBL;BindingDB
P29376 LTK Homo sapiens Human PF12810 PF07714 8.1 Ki ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 8.1 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 8.0 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 7.8 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.8 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 7.7 Ki ChEMBL
Q9UM73 ALK Homo sapiens Human PF12810 PF00629 PF07714 7.6 IC50 ChEMBL;BindingDB
P45984 MAPK9 Homo sapiens Human PF00069 7.4 IC50 ChEMBL
P06213 INSR Homo sapiens Human PF00757 PF17870 PF07714 PF01030 7.4 IC50 ChEMBL;BindingDB
Q07912 TNK2 Homo sapiens Human PF09027 PF11555 PF07714 PF22931 PF14604 7.4 Ki ChEMBL
Q13882 PTK6 Homo sapiens Human PF07714 PF00017 PF00018 7.3 Ki ChEMBL
Q15303 ERBB4 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 7.1 Ki ChEMBL
P08069 IGF1R Homo sapiens Human PF00757 PF07714 PF01030 7.1 IC50 ChEMBL;BindingDB
O43293 DAPK3 Homo sapiens Human PF00069 7.0 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 7.0 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 7.0 Ki ChEMBL
P07332 FES Homo sapiens Human PF00611 PF07714 PF00017 6.9 Ki ChEMBL
P08581 MET Homo sapiens Human PF07714 PF01437 PF01403 PF01833 6.7 Ki ChEMBL
P53350 PLK1 Homo sapiens Human PF00069 PF00659 6.7 Ki ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.7 Ki ChEMBL
P28482 MAPK1 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q08881 ITK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.6 Ki ChEMBL
O00311 CDC7 Homo sapiens Human PF00069 6.5 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.5 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.5 Ki ChEMBL
P15735 PHKG2 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P51957 NEK4 Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q02779 MAP3K10 Homo sapiens Human PF07714 PF14604 6.5 Ki ChEMBL
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 6.5 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.5 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.4 Ki ChEMBL
P50613 CDK7 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q96L34 MARK4 Homo sapiens Human PF02149 PF00069 PF00627 6.4 Ki ChEMBL
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 6.3 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.3 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P51617 IRAK1 Homo sapiens Human PF00531 PF00069 6.3 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.3 Ki ChEMBL
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.3 Ki ChEMBL
Q9NR20 DYRK4 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.3 IC50 ChEMBL;BindingDB
Q9H0K1 SIK2 Homo sapiens Human PF00069 PF23312 6.2 Ki ChEMBL
P04626 ERBB2 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.2 IC50 ChEMBL;BindingDB
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 6.1 IC50 ChEMBL;BindingDB
O43781 DYRK3 Homo sapiens Human PF00069 6.1 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.1 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.1 Ki ChEMBL
Q04912 MST1R Homo sapiens Human PF07714 PF01437 PF01403 PF01833 6.1 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.1 Ki ChEMBL
Q13555 CAMK2G Homo sapiens Human PF08332 PF00069 6.1 Ki ChEMBL
Q8TDC3 BRSK1 Homo sapiens Human PF21122 PF00069 PF21115 6.1 Ki ChEMBL
Q9H3Y6 SRMS Homo sapiens Human PF07714 PF00017 6.1 Ki ChEMBL
Q9Y463 DYRK1B Homo sapiens Human PF00069 6.1 Ki ChEMBL
O75460 ERN1 Homo sapiens Human PF00069 PF06479 6.1 IC50 BindingDB
O14757 CHEK1 Homo sapiens Human PF00069 6.0 Ki ChEMBL
P09619 PDGFRB Homo sapiens Human PF00047 PF13927 PF25305 PF07714 6.0 Ki ChEMBL
Q96SB4 SRPK1 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.0 Ki ChEMBL
DrugBank Target Actions (1)
Target Gene Target Name Action Type
Q05397 PTK2 Focal adhesion kinase 1 binder targets