Molecule Details
InChIKeyUXUQVXDYXKMCGA-UHFFFAOYSA-N
Compound Name4-(1H-indazol-5-yl)-6-phenylpyrimidin-2(1H)-one
Canonical SMILESO=c1nc(-c2ccc3[nH]ncc3c2)cc(-c2ccccc2)[nH]1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)21
Pfam Stratification Homologous
Avg pChEMBL6.71
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (21)
Target Gene Organism Category Pfam pChEMBL Type Source
O00311 CDC7 Homo sapiens Human PF00069 8.0 IC50 ChEMBL;BindingDB
Q13627 DYRK1A Homo sapiens Human PF00069 7.8 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 7.7 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 7.6 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 7.4 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 7.3 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 6.8 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q86V86 PIM3 Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q9NR20 DYRK4 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 6.4 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.2 Ki ChEMBL
P48730 CSNK1D Homo sapiens Human PF00069 6.2 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P28482 MAPK1 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.1 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.1 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 6.0 Ki ChEMBL
Q96PF2 TSSK2 Homo sapiens Human PF00069 6.0 Ki ChEMBL