1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-phenylurea

InChIKey	`UXMNYFJHEBEDJS-UHFFFAOYSA-N`
Compound Name	1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-phenylurea
Canonical SMILES	`Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	19
Pfam Stratification	Cross-Family
Avg pChEMBL	6.79
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P17948	FLT1	Homo sapiens	Human	PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	8.8	Ki	ChEMBL
P07333	CSF1R	Homo sapiens	Human	PF00047 PF25305 PF07714	8.2	Ki	ChEMBL
P10721	KIT	Homo sapiens	Human	PF00047 PF07714	7.4	IC50	ChEMBL;BindingDB
Q96GD4	AURKB	Homo sapiens	Human	PF00069	7.3	Ki	ChEMBL
P36888	FLT3	Homo sapiens	Human	PF00047 PF07714	7.3	IC50	ChEMBL;BindingDB
Q02161	RHD	Homo sapiens	Human	PF00909	7.2	pIC50	TTD_MultiTarget
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	7.2	IC50	ChEMBL;BindingDB
P51451	BLK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.8	Ki	ChEMBL
O00444	PLK4	Homo sapiens	Human	PF00069 PF18190 PF18409	6.5	Ki	ChEMBL
O75116	ROCK2	Homo sapiens	Human	PF25346 PF00069 PF08912	6.5	Ki	ChEMBL
O14965	AURKA	Homo sapiens	Human	PF00069	6.4	Ki	ChEMBL
P29597	TYK2	Homo sapiens	Human	PF18379 PF18377 PF17887 PF07714 PF21990	6.4	Ki	ChEMBL
P35916	FLT4	Homo sapiens	Human	PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	6.3	Ki	ChEMBL
O60674	JAK2	Homo sapiens	Human	PF18379 PF18377 PF17887 PF07714 PF21990	6.2	Ki	ChEMBL
Q13188	STK3	Homo sapiens	Human	PF11629 PF00069	6.2	Ki	ChEMBL
Q16620	NTRK2	Homo sapiens	Human	PF07679 PF13855 PF16920 PF01462 PF07714	6.2	Ki	ChEMBL
P07948	LYN	Homo sapiens	Human	PF07714 PF00017 PF00018	6.1	Ki	ChEMBL
Q13464	ROCK1	Homo sapiens	Human	PF25346 PF00069 PF08912	6.0	Ki	ChEMBL
Q9HBY8	SGK2	Homo sapiens	Human	PF00069 PF00433	6.0	Ki	ChEMBL